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Claude Desplan
Claude Desplan, a biologist originally trained in France, has been a Silver Professor in New York University’s Department of Biology since 1999. His research centers on understanding the development and functioning of the visual system that underlies color vision using the fruit fly Drosophila as a model organism.
== Biography ==
Desplan completed his undergraduate training at the Ecole Normale Supérieure in St. Cloud, France in 1975 and he received a Ph.D. at the Institut National de la Santé et de la Recherche Médicale (INSERM) in Paris in 1983. His thesis work, done under the guidance of Mohsen
Moukhtar and Monique Thomasset, focused on calcium regulation.
As a postdoctoral fellow in the laboratory of Pat O’Farrell at the University of California, San Francisco, Desplan worked on the functional specificity of homeodomain proteins. He demonstrated that this conserved signature of many developmental genes is a DNA binding motif.〔Desplan C., Theis J., O'Farrell P., The Drosophila developmental gene, engrailed, encodes a sequence specific DNA-binding activity. Nature, 318, 630-635 (1985).〕 In 1987, he joined the faculty of Rockefeller University and was named a Howard Hughes Medical Institute Assistant and Associate Investigator. There, he pursued structural and functional studies of the homeodomain and Paired domain DNA binding domains〔Treisman J., Gönczy P., Vashishta M., Harris E., Desplan C. A single amino acid can determine the specificity of homeodomain proteins. Cell, 59, 563-562 (1989)〕 and investigated the evolution of axis formation in insects. He accepted a position as Professor at New York University in 1999.
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